All additives
E421·humectant

Mannitol

Safe

Overview

Mannitol is a sugar alcohol (polyol) naturally occurring in mushrooms, seaweed, algae, and many plants. As a food additive it functions as a humectant, sweetener, and anti-caking agent in chewing gum, sugar-free confectionery, and baked goods. It provides about half the sweetness of sucrose with negligible blood glucose impact, making it popular in diabetic-friendly and reduced-sugar formulations. Unlike most sugars, it does not promote tooth decay.

JECFA's ADI is "not specified," evaluated in 1968. Mannitol is metabolised differently from glucose: a significant portion passes through the small intestine unabsorbed and is fermented by gut bacteria in the colon. At high doses (typically above 20 g per day), this fermentation produces gas and can cause osmotic diarrhoea — the same mechanism as other sugar alcohols. EU regulations require a warning statement on products with more than 10% added mannitol: "excessive consumption may produce laxative effects."

Mannitol is approved in the EU, US (GRAS), UK, Australia, and globally. It is found in sugar-free chewing gum, mints, diabetic confectionery, and some bakery products. For most consumers, dietary exposure from food additive use is well below the threshold for laxative effects. The non-cariogenic property and low glycaemic impact make it a valuable additive for oral health and metabolic management. There are no other known health concerns for healthy adults.

Generated from verified JECFA, EFSA, and regulatory data. All numerical values are sourced from the WHO/FAO JECFA Combined Compendium and EFSA OpenFoodTox 3.0.

Safety Assessment

BodyAcceptable Daily Intake (ADI)Year
JECFANot specified — no concern at typical intakes · JECFA 19681968
EFSA

ADI = the amount of a substance a person can consume every day over a lifetime without appreciable health risk. Expressed as mg per kg body weight per day. Source: WHO/FAO JECFA Combined Compendium; EFSA OpenFoodTox 3.0.

Scientific Notes

Sugar alcohol naturally present in mushrooms, seaweed, and many plants. Non-cariogenic and suitable for diabetics; laxative effect at high doses (>20 g/day).

Primary Sources